Sirtuin 1 regulation of developmental genes during differentiation of stem cells
نویسندگان
چکیده
منابع مشابه
Sirtuin 1 regulation of developmental genes during differentiation of stem cells.
The longevity-promoting NAD+-dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the p53-dependent expression of NANOG. We show that SIRT1 is down-regulated precisely during human embryonic stem cell differentiation at both mRNA and protein levels and that the decrease in Sirt1 mRNA is mediated by a m...
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Human Wharton’s jelly-derived mesenchymal stem cells express oocyte developmental genes during co-culture with placental cells
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1001399107